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NR 507 Midterm Specific StudyGuide (Spring 2018) | Complete Solution
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  1. Defects in the encoding of histone-modifying proteins (Chp 6 and 12 wk 1)
  2. Epigenetics and (45) its role on human development. (chp 6)
  3. Totipotent cells
  4. Angelman syndrome? – loss of the maternal copy of UBE3A

Cellular Proliferation

  1. 5-Azacytidine and the(44) treatment of cancer (Chap 6 & Chp 12- wk 1)
  2. the role of inactive MLH1 in the development of some forms of inherited colon cancer.
  3. Effects of ethanol on neural stem cells ability to differentiate into functional neurons (chap 13,wk 1) (Chap 2
  4. Inflammation as an etiology for cancer-note conditions in which this may occur 


  1. In terms of epigenetic modifications, the role of environmental stressors associated with development of cancer.

Defects in Mechanism of Defense

  1. Hemolytic defects in the newborn
  2. Understand the meaning of infectivity ( chap 10 )
  3. Most effective treatment for HIV-
  4. Defected cells of HIV
  5. Signs of T-Lymphocyte deficiency 

Pulmonary Alterations

  1. Pulmonary function tests
  2. Relationship of lung compliance and (46) residual volume
  3. Shifts in the oxyhemoglobin dissociation- (chap 3, 17, 34)
  4. CO2 transport in the blood ( chap 34)
  5. Characteristics of alveoli-
  6. Arterial perfusion pressure in the lung base and
  7. alveolar gas pressure in the lung base
  8. How do determine the partial pressure of oxygen given the percentage of oxygen in the air and
  9. (23) the barometric pressure
  10. Results of increased work of breathing Know terms: Chapter 34
  11. Vital capacity (VC),
  12. Total lung capacity
  13. Functional capacity-
  14. Residual volume (RV)
  15. Functional residual capacity (FRC) –

Renal Alterations

  1. Types of nephrons and (48) their functions (chap 37)
  2. Overall renal physiology-
  3. Substances that are actively secreted by the renal tubules (Chap39)
  4. Activation of the renin-angiotensin system
  5. Glomerular filtration rate- clearance
  6. Mesangial cells-
  7. Renal system anatomy
  8. Why plasma proteins should be absent from the urine-
  9. Effects of urinary tract obstruction- hydronephrosis and a
  10. (39) decreased glomerular filtration rate
  11. Effect of urinary retention
  12. Epispadias
  13. Glomerulonephritis- ( chap 38)
  14. Nephrotic syndrome- ( chap 38)
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NR 507 Midterm Specific StudyGuide (Spring 2018) | Complete Solution
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  • Submitted On 09 Jun, 2018 06:52:07
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Epigenetics 1.Defects in the encoding of histone-modifying proteins (Chp 6 and 12 wk 1) Histone modification (e.g., histone acetylation and deacetylation, alterations in chromatin): Chromatin compaction and organization help to regulate gene expression, determining and maintaining cell identity. Chromatin structure must be controlled in self-renewing and differentiated cells in cell renewal systems. For example, there are differences in chromatin structure in stem cells and terminally differentiated cells  are chemical modifications of ...
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